Found 3 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM145490' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM145490
(US8952169, 283)Show SMILES Fc1cc(O[C@H]2C3CC4CC2C[C@](Cl)(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |r,wU:5.4,wD:12.13,TLB:5:6:14:11.10.9,4:5:11:14.8.9,THB:5:10:14:6.7.15,7:6:11:14.8.9,7:8:11:6.5.15,(2.54,2.48,;1.21,1.71,;-.13,2.48,;-1.46,1.71,;-2.79,2.48,;-4.28,2.09,;-4.28,.55,;-5.18,-1.38,;-6.38,-.71,;-6.36,1.69,;-5.61,2.85,;-6.94,2.09,;-6.94,.55,;-8.43,.15,;-7.78,-1.36,;-5.61,-.23,;-1.46,.17,;-.13,-.6,;1.21,.17,;2.54,-.6,;2.54,-2.14,;3.88,.17,;5.21,-.6,;4.44,-1.93,;5.98,.74,;6.54,-1.37,;6.94,-2.85,;8.43,-2.46,;8.03,-.97,;-2.79,-.6,;-4.33,-.6,;-3.56,-1.93,)| Show InChI InChI=1S/C23H28ClFN2O4S/c24-23-10-13-6-15(11-23)21(16(7-13)12-23)31-20-9-19(25)18(8-17(20)14-2-3-14)22(28)26-32(29,30)27-4-1-5-27/h8-9,13-16,21H,1-7,10-12H2,(H,26,28)/t13?,15?,16?,21-,23- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc.
US Patent
| Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... |
US Patent US8952169 (2015)
BindingDB Entry DOI: 10.7270/Q2M04445 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM145490
(US8952169, 283)Show SMILES Fc1cc(O[C@H]2C3CC4CC2C[C@](Cl)(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |r,wU:5.4,wD:12.13,TLB:5:6:14:11.10.9,4:5:11:14.8.9,THB:5:10:14:6.7.15,7:6:11:14.8.9,7:8:11:6.5.15,(2.54,2.48,;1.21,1.71,;-.13,2.48,;-1.46,1.71,;-2.79,2.48,;-4.28,2.09,;-4.28,.55,;-5.18,-1.38,;-6.38,-.71,;-6.36,1.69,;-5.61,2.85,;-6.94,2.09,;-6.94,.55,;-8.43,.15,;-7.78,-1.36,;-5.61,-.23,;-1.46,.17,;-.13,-.6,;1.21,.17,;2.54,-.6,;2.54,-2.14,;3.88,.17,;5.21,-.6,;4.44,-1.93,;5.98,.74,;6.54,-1.37,;6.94,-2.85,;8.43,-2.46,;8.03,-.97,;-2.79,-.6,;-4.33,-.6,;-3.56,-1.93,)| Show InChI InChI=1S/C23H28ClFN2O4S/c24-23-10-13-6-15(11-23)21(16(7-13)12-23)31-20-9-19(25)18(8-17(20)14-2-3-14)22(28)26-32(29,30)27-4-1-5-27/h8-9,13-16,21H,1-7,10-12H2,(H,26,28)/t13?,15?,16?,21-,23- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assay |
J Med Chem 58: 7093-118 (2015)
Article DOI: 10.1021/jm501981g
BindingDB Entry DOI: 10.7270/Q2XS5X6P |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM145490
(US8952169, 283)Show SMILES Fc1cc(O[C@H]2C3CC4CC2C[C@](Cl)(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |r,wU:5.4,wD:12.13,TLB:5:6:14:11.10.9,4:5:11:14.8.9,THB:5:10:14:6.7.15,7:6:11:14.8.9,7:8:11:6.5.15,(2.54,2.48,;1.21,1.71,;-.13,2.48,;-1.46,1.71,;-2.79,2.48,;-4.28,2.09,;-4.28,.55,;-5.18,-1.38,;-6.38,-.71,;-6.36,1.69,;-5.61,2.85,;-6.94,2.09,;-6.94,.55,;-8.43,.15,;-7.78,-1.36,;-5.61,-.23,;-1.46,.17,;-.13,-.6,;1.21,.17,;2.54,-.6,;2.54,-2.14,;3.88,.17,;5.21,-.6,;4.44,-1.93,;5.98,.74,;6.54,-1.37,;6.94,-2.85,;8.43,-2.46,;8.03,-.97,;-2.79,-.6,;-4.33,-.6,;-3.56,-1.93,)| Show InChI InChI=1S/C23H28ClFN2O4S/c24-23-10-13-6-15(11-23)21(16(7-13)12-23)31-20-9-19(25)18(8-17(20)14-2-3-14)22(28)26-32(29,30)27-4-1-5-27/h8-9,13-16,21H,1-7,10-12H2,(H,26,28)/t13?,15?,16?,21-,23- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc.
US Patent
| Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... |
US Patent US8952169 (2015)
BindingDB Entry DOI: 10.7270/Q2M04445 |
More data for this
Ligand-Target Pair | |
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