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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM47138'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.90n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.90n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent




US Patent US9771376 (2017)


BindingDB Entry DOI: 10.7270/Q2W0983R
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair