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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sonic hedgehog protein' and Ligand = 'BDBM50443887'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sonic hedgehog protein


(Mus musculus (Mouse))		BDBM50443887
PNG
(CHEMBL3091554)
Show SMILES Cc1cccc(C)c1NC(=O)c1ccc(Nc2cc(ccn2)-c2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C27H22F3N3O2/c1-17-4-3-5-18(2)25(17)33-26(34)20-6-10-22(11-7-20)32-24-16-21(14-15-31-24)19-8-12-23(13-9-19)35-27(28,29)30/h3-16H,1-2H3,(H,31,32)(H,33,34)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Jiangsu Simcere Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay

Bioorg Med Chem Lett 23: 6777-83 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.022
BindingDB Entry DOI: 10.7270/Q2R49S7W
More data for this
Ligand-Target Pair