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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sonic hedgehog protein' and Ligand = 'BDBM50443903'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sonic hedgehog protein


(Mus musculus (Mouse))		BDBM50443903
PNG
(CHEMBL3091565)
Show SMILES Cc1ccccc1NC(=O)c1ccc(Nc2ncc(C)c(n2)-c2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C26H21F3N4O2/c1-16-5-3-4-6-22(16)32-24(34)19-7-11-20(12-8-19)31-25-30-15-17(2)23(33-25)18-9-13-21(14-10-18)35-26(27,28)29/h3-15H,1-2H3,(H,32,34)(H,30,31,33)
PDB

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Jiangsu Simcere Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay

Bioorg Med Chem Lett 23: 6777-83 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.022
BindingDB Entry DOI: 10.7270/Q2R49S7W
More data for this
Ligand-Target Pair