BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Substance-P receptor' and Ligand = 'BDBM50346327'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Substance-P receptor (Homo sapiens (Human))	BDBM50346327 ((S)-2-(4-acetamido-3-oxo-4,5-dihydro-1H-benzo[c]az...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	387	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting				J Med Chem 54: 2467-76 (2011) Article DOI: 10.1021/jm1016285 BindingDB Entry DOI: 10.7270/Q2416XD1
Vrije Universiteit Brussel Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50346327 ((S)-2-(4-acetamido-3-oxo-4,5-dihydro-1H-benzo[c]az...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Brussel Curated by ChEMBL					Assay Description Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine lumines...				J Med Chem 54: 2467-76 (2011) Article DOI: 10.1021/jm1016285 BindingDB Entry DOI: 10.7270/Q2416XD1
Vrije Universiteit Brussel Curated by ChEMBL					More data for this Ligand-Target Pair