Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synaptic vesicular amine transporter (Bos taurus) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wichita State University Curated by ChEMBL | Assay Description Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghosts | J Med Chem 51: 760-8 (2008) Article DOI: 10.1021/jm070875p BindingDB Entry DOI: 10.7270/Q2M909J6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 7.62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation counting | Eur J Med Chem 46: 1841-8 (2011) Article DOI: 10.1016/j.ejmech.2011.02.046 BindingDB Entry DOI: 10.7270/Q2251JHP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry | Bioorg Med Chem 18: 640-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.002 BindingDB Entry DOI: 10.7270/Q2XS5WB2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation counting | J Med Chem 52: 7878-82 (2009) Article DOI: 10.1021/jm900770h BindingDB Entry DOI: 10.7270/Q25X29V5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy | J Med Chem 52: 7878-82 (2009) Article DOI: 10.1021/jm900770h BindingDB Entry DOI: 10.7270/Q25X29V5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 8.30 | 5.20 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |