Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50068304 (CHEMBL343445 | N-[9,10-Dioxo-6-(3-pyrrolidin-1-yl-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibitory activity of telomerase was measured using the TRAP assay. | J Med Chem 41: 4873-84 (1998) Article DOI: 10.1021/jm981067o BindingDB Entry DOI: 10.7270/Q2WW7GSD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50068304 (CHEMBL343445 | N-[9,10-Dioxo-6-(3-pyrrolidin-1-yl-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi"Magna Gr£cia" Curated by ChEMBL | Assay Description Inhibition of telomerase (unknown origin) by TRAP assay | Eur J Med Chem 68: 139-49 (2013) Article DOI: 10.1016/j.ejmech.2013.07.022 BindingDB Entry DOI: 10.7270/Q24J0GJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50068304 (CHEMBL343445 | N-[9,10-Dioxo-6-(3-pyrrolidin-1-yl-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.78E+9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of telomerase in Homo sapiens (human) A549 cells after 24 hr by TRAP assay | Citation and Details Article DOI: 10.1007/s00044-011-9594-4 BindingDB Entry DOI: 10.7270/Q2X63QV3 | |||||||||||
More data for this Ligand-Target Pair |