BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Ligand = 'BDBM50126186'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HeLa cells after 2 hrs by [alpha-32P]dGTP incorporation assay				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of human telomerase isolated from human HeLa cells nuclear extracts expressed in insect cells assessed as [33P]dCMP incorporation after 30...				J Med Chem 57: 521-38 (2014) Article DOI: 10.1021/jm400528t BindingDB Entry DOI: 10.7270/Q2T43VKJ
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Anhui Medical University Curated by ChEMBL					Assay Description Inhibition of human telomerase				Eur J Med Chem 112: 231-51 (2016) Article DOI: 10.1016/j.ejmech.2016.02.009 BindingDB Entry DOI: 10.7270/Q2SB47N4
Anhui Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Guizhou University Curated by ChEMBL					Assay Description Inhibition of telomerase in human MDA-MB-231 cells after 24 hrs by TRAP-PCR-ELISA				Eur J Med Chem 97: 155-63 (2015) Article DOI: 10.1016/j.ejmech.2015.04.063 BindingDB Entry DOI: 10.7270/Q2PZ5BH7
Guizhou University Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Anhui Medical University Curated by ChEMBL					Assay Description Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA				Eur J Med Chem 74: 717-25 (2014) Article DOI: 10.1016/j.ejmech.2013.06.014 BindingDB Entry DOI: 10.7270/Q21G0NRG
Anhui Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Anhui Medical University Curated by ChEMBL					Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA				Eur J Med Chem 90: 889-96 (2015) Article DOI: 10.1016/j.ejmech.2014.12.013 BindingDB Entry DOI: 10.7270/Q29S1SP6
Anhui Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Anhui Medical University Curated by ChEMBL					Assay Description Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA				Eur J Med Chem 95: 166-73 (2015) Article DOI: 10.1016/j.ejmech.2015.03.039 BindingDB Entry DOI: 10.7270/Q2W097NH
Anhui Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of human telomerase activity isolated from HEK293 cells assessed as reduction in dNTP incorporation using 5'-biotinylated AATCCGTCGAGCAGAG...				Eur J Med Chem 125: 117-129 (2017) Article DOI: 10.1016/j.ejmech.2016.09.028 BindingDB Entry DOI: 10.7270/Q2NS0X5V
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...				J Med Chem 55: 3678-86 (2012) Article DOI: 10.1021/jm201191d BindingDB Entry DOI: 10.7270/Q2DF6SB3
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Southwestern Medical Center at Dallas Curated by ChEMBL					Assay Description Inhibitory activity of the compound against telomerase				Bioorg Med Chem Lett 13: 1333-6 (2003) BindingDB Entry DOI: 10.7270/Q2S46R9J
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50126186 (2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea...				Eur J Med Chem 125: 117-129 (2017) Article DOI: 10.1016/j.ejmech.2016.09.028 BindingDB Entry DOI: 10.7270/Q2NS0X5V
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair