BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Ligand = 'BDBM50134030'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL					Assay Description Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay				Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL					Assay Description Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay				Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Reims-Champagne-Ardenne Curated by ChEMBL					Assay Description Inhibition of human telomerase in A549 cells by TRAP assay				Eur J Med Chem 44: 3880-8 (2009) Article DOI: 10.1016/j.ejmech.2009.04.021 BindingDB Entry DOI: 10.7270/Q2W37WDH
Universit£ de Reims-Champagne-Ardenne Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Central University of Las Villas Curated by ChEMBL					Assay Description Inhibition of telomerase in human A2780 cells by TRAP assay				Eur J Med Chem 44: 4826-40 (2009) Article DOI: 10.1016/j.ejmech.2009.07.029 BindingDB Entry DOI: 10.7270/Q20R9PHM
Central University of Las Villas Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL					Assay Description Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assay				Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of human telomerase assessed as unincorporated [alpha32P]dGTP				Bioorg Med Chem 17: 2030-7 (2009) Article DOI: 10.1016/j.bmc.2009.01.015 BindingDB Entry DOI: 10.7270/Q2R49QNF
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a
University of London Curated by ChEMBL					Assay Description Inhibition of telomerase (unknown origin) by TRAP-LIG assay				J Med Chem 51: 7751-67 (2008) Article DOI: 10.1021/jm801245v BindingDB Entry DOI: 10.7270/Q2CN73SS
University of London Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	113	n/a	n/a	n/a	n/a
University of London School of Pharmacy Curated by ChEMBL					Assay Description Effective concentration against telomerase by TRAP				Bioorg Med Chem Lett 14: 4347-51 (2004) Article DOI: 10.1016/j.bmcl.2004.05.090 BindingDB Entry DOI: 10.7270/Q2KD1XDZ
University of London School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
University of London Curated by ChEMBL					Assay Description Inhibition of human telomerase by TRAP assay				Bioorg Med Chem Lett 17: 2293-8 (2007) Article DOI: 10.1016/j.bmcl.2007.01.056 BindingDB Entry DOI: 10.7270/Q2JW8FQC
University of London Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	115	n/a	n/a	n/a	n/a
University of London Curated by ChEMBL					Assay Description Inhibitory activity against human telomerase				J Med Chem 46: 4463-76 (2003) Article DOI: 10.1021/jm0308693 BindingDB Entry DOI: 10.7270/Q2RR1XN3
University of London Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50134030 (9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	113	n/a	n/a	n/a	n/a
University of London Curated by ChEMBL					Assay Description Inhibition of telomerase activity from human A2780 cells				J Med Chem 49: 582-99 (2006) Article DOI: 10.1021/jm050555a BindingDB Entry DOI: 10.7270/Q2CN73GR
University of London Curated by ChEMBL					More data for this Ligand-Target Pair