BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' and Ligand = 'BDBM50231043'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50231043 (CHEMBL400086 \| N-(4-tert-butylphenyl)-4-(1,1,2,2-t...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced calcium influx in HEK293 cells				Bioorg Med Chem Lett 18: 1072-8 (2008) Article DOI: 10.1016/j.bmcl.2007.12.007 BindingDB Entry DOI: 10.7270/Q2PZ58K9
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50231043 (CHEMBL400086 \| N-(4-tert-butylphenyl)-4-(1,1,2,2-t...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 assessed as inhibition of capsaicin-induced calcium mobilization				Bioorg Med Chem Lett 18: 1072-8 (2008) Article DOI: 10.1016/j.bmcl.2007.12.007 BindingDB Entry DOI: 10.7270/Q2PZ58K9
Pfizer Global Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair