Found 5 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 4' and Ligand = 'BDBM50192823' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of hypotonic solution-induced calcium mobilization by F... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013 BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013 BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activation |
Bioorg Med Chem Lett 26: 4936-4941 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.014 BindingDB Entry DOI: 10.7270/Q2154K06 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Rattus norvegicus) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activation |
Bioorg Med Chem Lett 26: 4936-4941 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.014 BindingDB Entry DOI: 10.7270/Q2154K06 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Rattus norvegicus) | BDBM50192823
(CHEMBL3906074)Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1 Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi& Co., Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 300 nM 4alphaPDD-induced calcium mobilization by FLIPR... |
Bioorg Med Chem Lett 26: 4930-4935 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.013 BindingDB Entry DOI: 10.7270/Q2BC41H5 |
More data for this Ligand-Target Pair | |