Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50126144 (CHEMBL3629569 | US10155972, Compound NewLink 1 | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptopha... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116160 BindingDB Entry DOI: 10.7270/Q2DF6W0V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50126144 (CHEMBL3629569 | US10155972, Compound NewLink 1 | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptopha... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116160 BindingDB Entry DOI: 10.7270/Q2DF6W0V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50126144 (CHEMBL3629569 | US10155972, Compound NewLink 1 | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Iomet Pharma Ltd. US Patent | Assay Description In two separate assays, 0.045 μg/μl of human IDO protein was pre-incubated for 10 min at RT with test compounds NewLink 1 and Incyte 1 in t... | US Patent US10155972 (2018) BindingDB Entry DOI: 10.7270/Q2HT2RDS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50126144 (CHEMBL3629569 | US10155972, Compound NewLink 1 | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
Iomet Pharma Ltd. US Patent | Assay Description In two separate assays, 2.5 μg/μl of human TDO protein was pre-incubated for 10 minutes at RT with test compounds 680C91 and LM10 in the pr... | US Patent US10155972 (2018) BindingDB Entry DOI: 10.7270/Q2HT2RDS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50126144 (CHEMBL3629569 | US10155972, Compound NewLink 1 | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado College Curated by ChEMBL | Assay Description Inhibition of TDO (unknown origin) | J Med Chem 58: 8762-82 (2015) Article DOI: 10.1021/acs.jmedchem.5b00461 BindingDB Entry DOI: 10.7270/Q2C82C3F | |||||||||||
More data for this Ligand-Target Pair |