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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tryptophan 2,3-dioxygenase' and Ligand = 'BDBM50205731'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))		BDBM50205731
PNG
(CHEMBL3967430)
Show SMILES CC1N(CCS(N)(=O)=O)S(=O)(=O)c2ccc(cc12)-c1c[nH]c2cc(F)ccc12
Show InChI InChI=1S/C18H18FN3O4S2/c1-11-15-8-12(16-10-21-17-9-13(19)3-4-14(16)17)2-5-18(15)28(25,26)22(11)6-7-27(20,23)24/h2-5,8-11,21H,6-7H2,1H3,(H2,20,23,24)
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of TDO2 in human A172 cells assessed as kynurenine formation after overnight incubation

ACS Med Chem Lett 8: 11-13 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00458
BindingDB Entry DOI: 10.7270/Q2CZ395S
More data for this
Ligand-Target Pair