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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine kinase receptor A (TrkA)' and Ligand = 'BDBM227000'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM227000
PNG
(US9328096, 688)
Show SMILES COc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)ccn1
Show InChI InChI=1S/C29H22ClFN6O3/c1-40-27-13-18(10-12-33-27)17-34-29(39)25-16-26(37(36-25)19-7-3-2-4-8-19)35-28(38)20-14-21(23(31)15-22(20)30)24-9-5-6-11-32-24/h2-16H,17H2,1H3,(H,34,39)(H,35,38)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.56n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair