Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM143321'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM143321 (US8940893, 6) Show SMILES Cn1c(Cc2ccccc2)ncc(-c2ccc(-c3nn(C4CC5(C4)CN(C5)C(=O)C=C)c4ncnc(N)c34)c(F)c2)c1=O Show InChI InChI=1S/C32H29FN8O2/c1-3-26(42)40-16-32(17-40)13-21(14-32)41-30-27(29(34)36-18-37-30)28(38-41)22-10-9-20(12-24(22)33)23-15-35-25(39(2)31(23)43)11-19-7-5-4-6-8-19/h3-10,12,15,18,21H,1,11,13-14,16-17H2,2H3,(H2,34,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description An HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...				US Patent US8940893 (2015) BindingDB Entry DOI: 10.7270/Q2PV6J3P
					More data for this Ligand-Target Pair