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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM143326'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM143326
PNG
(US8940893, 11)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cn3)c12)C1CC2(C1)CN(C2)C(=O)C=C
Show InChI InChI=1S/C25H23N7O2/c1-2-20(33)31-13-25(14-31)10-16(11-25)32-24-21(23(26)28-15-29-24)22(30-32)19-9-8-18(12-27-19)34-17-6-4-3-5-7-17/h2-9,12,15-16H,1,10-11,13-14H2,(H2,26,28,29)
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
An HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...


US Patent US8940893 (2015)


BindingDB Entry DOI: 10.7270/Q2PV6J3P
More data for this
Ligand-Target Pair