Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM143328'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM143328 (US8940893, 13) Show SMILES CC#CC(=O)N1CC[C@]2(C[C@@H](C2)n2nc(-c3ccc(Oc4ccccc4)cn3)c3c(N)ncnc23)C1 |r,wU:10.12,wD:8.8,(-10.43,-5.25,;-8.89,-5.25,;-7.35,-5.25,;-5.81,-5.25,;-5.04,-6.58,;-5.04,-3.92,;-5.52,-2.45,;-4.27,-1.55,;-3.03,-2.45,;-1.69,-3.22,;-.92,-1.89,;-2.26,-1.12,;.57,-1.49,;1.19,-.08,;2.73,-.08,;3.5,1.25,;2.73,2.58,;3.5,3.92,;5.04,3.92,;5.81,5.25,;7.35,5.25,;8.12,3.92,;9.66,3.92,;10.43,5.25,;9.66,6.58,;8.12,6.58,;5.81,2.58,;5.04,1.25,;3.04,-1.75,;4.38,-2.52,;5.71,-1.75,;4.38,-4.06,;3.04,-4.83,;1.71,-4.06,;1.71,-2.52,;-3.5,-3.92,)| Show InChI InChI=1S/C27H25N7O2/c1-2-6-22(35)33-12-11-27(16-33)13-18(14-27)34-26-23(25(28)30-17-31-26)24(32-34)21-10-9-20(15-29-21)36-19-7-4-3-5-8-19/h3-5,7-10,15,17-18H,11-14,16H2,1H3,(H2,28,30,31)/t18-,27+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description An HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...				US Patent US8940893 (2015) BindingDB Entry DOI: 10.7270/Q2PV6J3P
					More data for this Ligand-Target Pair