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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM202142'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM202142
PNG
(US9233983, I-13)
Show SMILES OCc1c(cccc1-c1ccnc2[nH]c(cc12)-c1ccc(CN2CCN(CC2)C2COC2)cn1)N1CCOc2cc(cc(F)c2C1=O)C1CC1
Show InChI InChI=1S/C39H39FN6O4/c40-32-16-26(25-5-6-25)17-36-37(32)39(48)46(14-15-50-36)35-3-1-2-28(31(35)21-47)29-8-9-41-38-30(29)18-34(43-38)33-7-4-24(19-42-33)20-44-10-12-45(13-11-44)27-22-49-23-27/h1-4,7-9,16-19,25,27,47H,5-6,10-15,20-23H2,(H,41,43)
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US Patent
n/an/a 2n/an/an/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on t...

US Patent US9233983 (2016)


BindingDB Entry DOI: 10.7270/Q22J69PQ
More data for this
Ligand-Target Pair