Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM288519'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM288519 ((1S,3S)-3-[8-amino-1- (2-ethoxy-6-fluoro-4- {[4- (...) Show SMILES CCOc1cc(cc(F)c1-c1nc(n2ccnc(N)c12)[C@@]1(C)CC[C@@](C)(C1)C(O)=O)C(=O)Nc1cc(ccn1)C(F)(F)F |r,wU:24.30,20.23,wD:24.27,(4.71,-3.47,;3.63,-2.38,;2.14,-2.78,;1.05,-1.69,;1.45,-.2,;.36,.89,;-1.13,.49,;-1.53,-1,;-3.02,-1.4,;-.44,-2.09,;-.84,-3.57,;.07,-4.82,;-.84,-6.07,;-2.3,-5.59,;-3.64,-6.36,;-4.97,-5.59,;-4.97,-4.05,;-3.64,-3.28,;-3.64,-1.74,;-2.3,-4.05,;-.07,-7.4,;-1.61,-7.4,;-.07,-8.94,;1.4,-9.42,;2.3,-8.17,;3.64,-8.94,;1.4,-6.92,;3.64,-7.4,;4.97,-8.17,;3.64,-5.86,;.76,2.38,;-.33,3.47,;2.24,2.77,;2.64,4.26,;1.55,5.35,;1.95,6.84,;3.44,7.24,;4.53,6.15,;4.13,4.66,;.86,7.93,;-.62,7.53,;1.26,9.42,;-.23,9.02,)| Show InChI InChI=1S/C29H28F4N6O4/c1-4-43-18-12-15(24(40)37-19-13-16(5-8-35-19)29(31,32)33)11-17(30)20(18)21-22-23(34)36-9-10-39(22)25(38-21)27(2)6-7-28(3,14-27)26(41)42/h5,8-13H,4,6-7,14H2,1-3H3,(H2,34,36)(H,41,42)(H,35,37,40)/t27-,28-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...				US Patent US10087188 (2018) BindingDB Entry DOI: 10.7270/Q2GF0WJC
					More data for this Ligand-Target Pair