Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM36521 (6-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of BTK (unknown origin) by Lanthascreen method | Bioorg Med Chem Lett 25: 1333-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.032 BindingDB Entry DOI: 10.7270/Q26Q1ZXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM36521 (6-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 650 | n/a | n/a | n/a | n/a | 7.5 | 23 |
CGI Pharmaceuticals | Assay Description Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen. | Nat Chem Biol 7: 41-50 (2011) Article DOI: 10.1038/nchembio.481 BindingDB Entry DOI: 10.7270/Q2B56H2T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Tyrosine-protein kinase BTK (Mus musculus) | BDBM36521 (6-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of BTK-mediated CD86 surface expression in Balb/c mouse splenocytes preincubated for 60 mins before F(ab')2 anti-mouse IgM measured after ... | Bioorg Med Chem Lett 25: 1333-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.032 BindingDB Entry DOI: 10.7270/Q26Q1ZXS | |||||||||||
More data for this Ligand-Target Pair |