Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM159766'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM159766 (US10966980, Example 17B | US9035074, 17B) Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N1CC[C@@H](C1)C#N)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,13.16,(-5.79,1.48,;-4.45,.71,;-3.12,1.48,;-2.72,2.97,;-1.23,2.57,;-1.63,1.09,;.1,3.34,;1.43,2.57,;.66,1.24,;2.2,3.91,;2.77,1.8,;4.25,2.27,;5.15,1.03,;4.25,-.22,;2.78,.26,;5.02,-1.55,;5.79,-2.89,;-4.45,-.83,;-5.79,-1.6,;-5.79,-3.14,;-4.45,-3.91,;-3.12,-3.14,;-1.66,-3.61,;-.75,-2.37,;-1.66,-1.12,;-3.12,-1.6,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...				US Patent US10966980 (2021) BindingDB Entry DOI: 10.7270/Q29S1V59
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM159766 (US10966980, Example 17B | US9035074, 17B) Show SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N1CC[C@@H](C1)C#N)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,13.16,(-5.79,1.48,;-4.45,.71,;-3.12,1.48,;-2.72,2.97,;-1.23,2.57,;-1.63,1.09,;.1,3.34,;1.43,2.57,;.66,1.24,;2.2,3.91,;2.77,1.8,;4.25,2.27,;5.15,1.03,;4.25,-.22,;2.78,.26,;5.02,-1.55,;5.79,-2.89,;-4.45,-.83,;-5.79,-1.6,;-5.79,-3.14,;-4.45,-3.91,;-3.12,-3.14,;-1.66,-3.61,;-.75,-2.37,;-1.66,-1.12,;-3.12,-1.6,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	25
Pfizer Inc. US Patent					Assay Description Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...				US Patent US9035074 (2015) BindingDB Entry DOI: 10.7270/Q26H4G56
					More data for this Ligand-Target Pair