Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM286099 (N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
YANG JI CHEMICAL CO., LTD.; HAN WHA PHARMA CO., LTD. US Patent | Assay Description Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as... | US Patent US10081635 (2018) BindingDB Entry DOI: 10.7270/Q2R213D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM286099 (N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | n/a |
YANG JI CHEMICAL CO., LTD.; HAN WHA PHARMA CO., LTD. US Patent | Assay Description Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as... | US Patent US10081635 (2018) BindingDB Entry DOI: 10.7270/Q2R213D4 | |||||||||||
More data for this Ligand-Target Pair |