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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM324572'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM324572
PNG
(1-(4-methylpiperazin-1- yl)-2-[4-[[8-[8-(4- (trifl...)
Show SMILES CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3S(=O)(=O)c2ccc(cc2)C(F)(F)F)cn1
Show InChI InChI=1S/C29H33F3N10O3S/c1-37-11-13-38(14-12-37)26(43)19-40-16-21(15-33-40)34-28-35-27-25(3-2-10-41(27)36-28)39-17-22-6-7-23(18-39)42(22)46(44,45)24-8-4-20(5-9-24)29(30,31)32/h2-5,8-10,15-16,22-23H,6-7,11-14,17-19H2,1H3,(H,34,36)
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US Patent
 0.200n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

US Patent US10189836 (2019)


BindingDB Entry DOI: 10.7270/Q2G162XH
More data for this
Ligand-Target Pair