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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM366448'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM366448
PNG
(4-[[8-[4- (cyanomethyl)-4- phenyl-1-piperidyl]- [1...)
Show SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CC#N)(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C33H38N8O/c1-38-21-14-28(15-22-38)39(2)31(42)25-10-12-27(13-11-25)35-32-36-30-29(9-6-20-41(30)37-32)40-23-17-33(16-19-34,18-24-40)26-7-4-3-5-8-26/h3-13,20,28H,14-18,21-24H2,1-2H3,(H,35,37)
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 2.05n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair