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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM366692'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM366692
PNG
(2-[4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1...)
Show SMILES OCC1(CCN(CC1)c1cccn2nc(Nc3cnn(CC(=O)N4CCC(CN5CCOCC5)CC4)c3)nc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H42ClN9O3/c34-27-5-3-26(4-6-27)33(24-44)9-14-40(15-10-33)29-2-1-11-43-31(29)37-32(38-43)36-28-20-35-42(22-28)23-30(45)41-12-7-25(8-13-41)21-39-16-18-46-19-17-39/h1-6,11,20,22,25,44H,7-10,12-19,21,23-24H2,(H,36,38)
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US Patent
 0.260n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair