Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM116317'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM116317 (US8637526, 297) Show SMILES O=C(NC1CCOCC1)c1cnn2ccc(NC3Cc4ccccc4C3)nc12 Show InChI InChI=1S/C21H23N5O2/c27-21(24-16-6-9-28-10-7-16)18-13-22-26-8-5-19(25-20(18)26)23-17-11-14-3-1-2-4-15(14)12-17/h1-5,8,13,16-17H,6-7,9-12H2,(H,23,25)(H,24,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.60	-49.7	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description To determine the inhibition constants (Ki), compounds were diluted serially in DMSO and added to 50 kinase reactions containing 0.2 nM purified JAK2 ...				US Patent US8637526 (2014) BindingDB Entry DOI: 10.7270/Q25719Q3
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