Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM232610'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232610 (US9346815, 156 | US9604984, Example 156) Show SMILES CCNC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C28H31ClF2N8O3/c1-2-32-24(40)5-3-11-37-13-8-19(9-14-37)39-17-22(35-27(41)21-16-34-38-12-4-10-33-26(21)38)25(36-39)20-15-18(29)6-7-23(20)42-28(30)31/h4,6-7,10,12,15-17,19,28H,2-3,5,8-9,11,13-14H2,1H3,(H,32,40)(H,35,41)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9604984 (2017) BindingDB Entry DOI: 10.7270/Q26D5W25
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM232610 (US9346815, 156 | US9604984, Example 156) Show SMILES CCNC(=O)CCCN1CCC(CC1)n1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F Show InChI InChI=1S/C28H31ClF2N8O3/c1-2-32-24(40)5-3-11-37-13-8-19(9-14-37)39-17-22(35-27(41)21-16-34-38-12-4-10-33-26(21)38)25(36-39)20-15-18(29)6-7-23(20)42-28(30)31/h4,6-7,10,12,15-17,19,28H,2-3,5,8-9,11,13-14H2,1H3,(H,32,40)(H,35,41)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.190	-54.9	n/a	n/a	n/a	n/a	n/a	7.2	22
Genentech, Inc. US Patent					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				US Patent US9346815 (2016) BindingDB Entry DOI: 10.7270/Q2NS0SRT
					More data for this Ligand-Target Pair