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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM324486'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM324486
PNG
(1-(4-ethylpiperazin-1-yl)- 2-[4-[[8-[8-[3- (triflu...)
Show SMILES CCN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3C(=O)N2CC(C2)C(F)(F)F)cn1
Show InChI InChI=1S/C28H36F3N11O2/c1-2-36-8-10-37(11-9-36)24(43)18-40-15-20(12-32-40)33-26-34-25-23(4-3-7-41(25)35-26)38-16-21-5-6-22(17-38)42(21)27(44)39-13-19(14-39)28(29,30)31/h3-4,7,12,15,19,21-22H,2,5-6,8-11,13-14,16-18H2,1H3,(H,33,35)
PDB

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US Patent
 0.5n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

US Patent US10189836 (2019)


BindingDB Entry DOI: 10.7270/Q2G162XH
More data for this
Ligand-Target Pair