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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM324569'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM324569
PNG
(1-(4-methylpiperazin-1- yl)-2-[4-[[8-[8-(2- methyl...)
Show SMILES CSc1ccccc1S(=O)(=O)N1C2CCC1CN(C2)c1cccn2nc(Nc3cnn(CC(=O)N4CCN(C)CC4)c3)nc12
Show InChI InChI=1S/C29H36N10O3S2/c1-34-12-14-35(15-13-34)27(40)20-37-17-21(16-30-37)31-29-32-28-24(6-5-11-38(28)33-29)36-18-22-9-10-23(19-36)39(22)44(41,42)26-8-4-3-7-25(26)43-2/h3-8,11,16-17,22-23H,9-10,12-15,18-20H2,1-2H3,(H,31,33)
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US Patent
 0.400n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

US Patent US10189836 (2019)


BindingDB Entry DOI: 10.7270/Q2G162XH
More data for this
Ligand-Target Pair