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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM366678'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM366678
PNG
(US9873709, Example 1-275 | [4-[[8-[4-(4- chlorophe...)
Show SMILES CN1CCC2CN(CC12)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C32H36ClN7O2/c1-37-16-12-23-19-39(20-28(23)37)30(42)22-4-10-26(11-5-22)34-31-35-29-27(3-2-15-40(29)36-31)38-17-13-32(21-41,14-18-38)24-6-8-25(33)9-7-24/h2-11,15,23,28,41H,12-14,16-21H2,1H3,(H,34,36)
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US Patent
 0.140n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair