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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM366680'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM366680
PNG
(4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- p...)
Show SMILES C[C@H]1CN(CCNC(=O)c2ccc(Nc3nc4c(cccn4n3)N3CCC(CO)(CC3)c3ccc(Cl)cc3)cc2)C[C@H](C)O1 |r|
Show InChI InChI=1S/C33H40ClN7O3/c1-23-20-39(21-24(2)44-23)19-15-35-31(43)25-5-11-28(12-6-25)36-32-37-30-29(4-3-16-41(30)38-32)40-17-13-33(22-42,14-18-40)26-7-9-27(34)10-8-26/h3-12,16,23-24,42H,13-15,17-22H2,1-2H3,(H,35,43)(H,36,38)/t23-,24-/m0/s1
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US Patent
 0.240n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair