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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM366683'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM366683
PNG
(4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- p...)
Show SMILES OCC1(CCN(CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)NC3CCN(CC3)C3CCCC3)nc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C35H42ClN7O2/c36-27-11-9-26(10-12-27)35(24-44)17-22-42(23-18-35)31-6-3-19-43-32(31)39-34(40-43)38-28-13-7-25(8-14-28)33(45)37-29-15-20-41(21-16-29)30-4-1-2-5-30/h3,6-14,19,29-30,44H,1-2,4-5,15-18,20-24H2,(H,37,45)(H,38,40)
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US Patent
 0.230n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair