Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM366921'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366921 (4,4,4-trifluoro-1-[4-[2- [4-[4-(5-methyl-2- pyridy...) Show SMILES Cc1ccc(nc1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1 |t:33| Show InChI InChI=1S/C33H34F3N7O2/c1-22-4-9-28(37-21-22)24-13-19-42(20-14-24)31(45)25-5-7-26(8-6-25)38-32-39-30-27(3-2-16-43(30)40-32)23-11-17-41(18-12-23)29(44)10-15-33(34,35)36/h2-9,11,16,21,24H,10,12-15,17-20H2,1H3,(H,38,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair