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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50361216'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50361216
PNG
(CHEMBL1934345)
Show SMILES COc1cccnc1-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12
Show InChI InChI=1S/C25H27N7O2/c1-34-22-3-2-12-27-24(22)21-9-8-20-15-28-25(30-32(20)21)29-19-6-4-17(5-7-19)18-10-13-31(14-11-18)16-23(26)33/h2-9,12,15,18H,10-11,13-14,16H2,1H3,(H2,26,33)(H,29,30)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 22: 133-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.049
BindingDB Entry DOI: 10.7270/Q2C829R4
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50361216
PNG
(CHEMBL1934345)
Show SMILES COc1cccnc1-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12
Show InChI InChI=1S/C25H27N7O2/c1-34-22-3-2-12-27-24(22)21-9-8-20-15-28-25(30-32(20)21)29-19-6-4-17(5-7-19)18-10-13-31(14-11-18)16-23(26)33/h2-9,12,15,18H,10-11,13-14,16H2,1H3,(H2,26,33)(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.14E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 22: 133-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.049
BindingDB Entry DOI: 10.7270/Q2C829R4
More data for this
Ligand-Target Pair