Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50449382'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449382 (CHEMBL3126340) Show SMILES Fc1cc(F)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(F)c1 Show InChI InChI=1S/C17H9F3N4O/c18-8-5-11(19)15(12(20)6-8)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50449382 (CHEMBL3126340) Show SMILES Fc1cc(F)c(Nc2nc3ccncc3c3c2cc[nH]c3=O)c(F)c1 Show InChI InChI=1S/C17H9F3N4O/c18-8-5-11(19)15(12(20)6-8)24-16-9-1-4-22-17(25)14(9)10-7-21-3-2-13(10)23-16/h1-7H,(H,22,25)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay				Bioorg Med Chem Lett 24: 1466-71 (2014) Article DOI: 10.1016/j.bmcl.2014.02.011 BindingDB Entry DOI: 10.7270/Q2D22034
					More data for this Ligand-Target Pair