Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM153161'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM153161 (US8993756, 4-3) Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cncc(NC(=O)C(C)=C)c3)c12 Show InChI InChI=1S/C18H17N5O3/c1-4-26-18(25)13-8-20-16-14(13)15(21-9-22-16)11-5-12(7-19-6-11)23-17(24)10(2)3/h5-9H,2,4H2,1,3H3,(H,23,24)(H,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0850	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US8993756 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31DJ
					More data for this Ligand-Target Pair