Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of JAK3 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min... | J Med Chem 59: 733-49 (2016) Article DOI: 10.1021/acs.jmedchem.5b01857 BindingDB Entry DOI: 10.7270/Q2057HSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ... | US Patent US10766894 (2020) BindingDB Entry DOI: 10.7270/Q2TX3JDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >400 | n/a | n/a | n/a | n/a | n/a | n/a |
Konkuk University Curated by ChEMBL | Assay Description Inhibition of JAK3 (unknown origin) | J Med Chem 58: 7596-602 (2015) Article DOI: 10.1021/acs.jmedchem.5b01263 BindingDB Entry DOI: 10.7270/Q2H70HND | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >400 | n/a | n/a | n/a | n/a | n/a | n/a |
Central China Normal University Curated by ChEMBL | Assay Description Inhibition of recombinant epitope tagged JAK3 kinase domain (718 to 1124 residues) (unknown origin) using peptide substrate by fluorescence based ass... | Bioorg Med Chem 27: 2592-2597 (2019) Article DOI: 10.1016/j.bmc.2019.03.048 BindingDB Entry DOI: 10.7270/Q25D8W5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | US Patent | n/a | n/a | >400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o... | Citation and Details BindingDB Entry DOI: 10.7270/Q290271H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Central China Normal University Curated by ChEMBL | Assay Description Inhibition of JAK3 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ... | Bioorg Med Chem 27: 2592-2597 (2019) Article DOI: 10.1016/j.bmc.2019.03.048 BindingDB Entry DOI: 10.7270/Q25D8W5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 787 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of JAK3 (unknown origin) | J Med Chem 57: 5023-38 (2014) Article DOI: 10.1021/jm401490p BindingDB Entry DOI: 10.7270/Q2ZS2Z3X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 787 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113394 BindingDB Entry DOI: 10.7270/Q2K64NT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50021656 (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 787 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of JAK3 (unknown origin) | Bioorg Med Chem 24: 2660-72 (2016) Article DOI: 10.1016/j.bmc.2016.04.030 BindingDB Entry DOI: 10.7270/Q25X2BVK | |||||||||||
More data for this Ligand-Target Pair |