Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50095984'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50095984 (CHEMBL3593761) Show SMILES C[C@@H]1CCCC[C@@H]1Nc1c(cnc2[nH]ccc12)C(N)=O |r| Show InChI InChI=1S/C20H25N5O5/c1-2-11(12-6-4-3-5-7-12)9-29-20-23-17(21)14-18(24-20)25(10-22-14)19-16(28)15(27)13(8-26)30-19/h3-7,10-11,13,15-16,19,26-28H,2,8-9H2,1H3,(H2,21,23,24)/t11-,13-,15+,16+,19?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA method				Bioorg Med Chem 23: 4871-83 (2015) Article DOI: 10.1016/j.bmc.2015.05.034 BindingDB Entry DOI: 10.7270/Q2DZ0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50095984 (CHEMBL3593761) Show SMILES C[C@@H]1CCCC[C@@H]1Nc1c(cnc2[nH]ccc12)C(N)=O |r| Show InChI InChI=1S/C20H25N5O5/c1-2-11(12-6-4-3-5-7-12)9-29-20-23-17(21)14-18(24-20)25(10-22-14)19-16(28)15(27)13(8-26)30-19/h3-7,10-11,13,15-16,19,26-28H,2,8-9H2,1H3,(H2,21,23,24)/t11-,13-,15+,16+,19?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of human JAK3 assessed as reduction in phosphorylation of Biotin-Lyn-Substrate-2 after 1 hr in presence of ATP by ELISA				Bioorg Med Chem 24: 4711-4722 (2016) Article DOI: 10.1016/j.bmc.2016.08.007 BindingDB Entry DOI: 10.7270/Q2RJ4NZW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50095984 (CHEMBL3593761) Show SMILES C[C@@H]1CCCC[C@@H]1Nc1c(cnc2[nH]ccc12)C(N)=O |r| Show InChI InChI=1S/C20H25N5O5/c1-2-11(12-6-4-3-5-7-12)9-29-20-23-17(21)14-18(24-20)25(10-22-14)19-16(28)15(27)13(8-26)30-19/h3-7,10-11,13,15-16,19,26-28H,2,8-9H2,1H3,(H2,21,23,24)/t11-,13-,15+,16+,19?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of JAK3 (unknown origin)				Bioorg Med Chem 26: 4971-4983 (2018) Article DOI: 10.1016/j.bmc.2018.08.005 BindingDB Entry DOI: 10.7270/Q2Z89G3M
					More data for this Ligand-Target Pair