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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Lck' and Ligand = 'BDBM50194698'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50194698
PNG
(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Show SMILES Cc1ccc(cc1-c1ccc2nc(NCCN3CCCCC3)ncc2c1)C(=O)Nc1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C31H32F3N5O/c1-20-9-10-23(29(40)37-27-8-6-7-26(21(27)2)31(32,33)34)18-25(20)22-11-12-28-24(17-22)19-36-30(38-28)35-13-16-39-14-4-3-5-15-39/h6-12,17-19H,3-5,13-16H2,1-2H3,(H,37,40)(H,35,36,38)
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PC sid
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF kinase assay


J Med Chem 49: 5671-86 (2006)


Article DOI: 10.1021/jm0605482
BindingDB Entry DOI: 10.7270/Q29G5MFD
More data for this
Ligand-Target Pair