Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Mer' and Ligand = 'BDBM50384609'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM50384609 (CHEMBL2036802 | US9744172, Compound UNC00000546A) Show SMILES COc1ccc(CNc2ncc3c(nn(CC4CCC(N)CC4)c3n2)-c2ccccc2)cc1 |(30.43,6.19,;29.1,5.42,;29.1,3.88,;30.43,3.11,;30.43,1.57,;29.09,.81,;29.09,-.73,;30.43,-1.5,;31.76,-.74,;31.76,.81,;33.09,1.58,;34.43,.82,;35.9,1.3,;36.81,.04,;35.9,-1.21,;36.38,-2.68,;35.35,-3.82,;33.84,-3.49,;32.81,-4.63,;33.28,-6.1,;32.24,-7.24,;34.79,-6.42,;35.83,-5.28,;34.43,-.74,;33.09,-1.51,;36.38,2.76,;37.88,3.08,;38.36,4.54,;37.33,5.69,;35.82,5.36,;35.35,3.9,;27.77,1.57,;27.76,3.1,)| Show InChI InChI=1S/C26H30N6O/c1-33-22-13-9-18(10-14-22)15-28-26-29-16-23-24(20-5-3-2-4-6-20)31-32(25(23)30-26)17-19-7-11-21(27)12-8-19/h2-6,9-10,13-14,16,19,21H,7-8,11-12,15,17,27H2,1H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...				ACS Med Chem Lett 3: 129-134 (2012) Article DOI: 10.1021/ml200239k BindingDB Entry DOI: 10.7270/Q2F76DMC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM50384609 (CHEMBL2036802 | US9744172, Compound UNC00000546A) Show SMILES COc1ccc(CNc2ncc3c(nn(CC4CCC(N)CC4)c3n2)-c2ccccc2)cc1 |(30.43,6.19,;29.1,5.42,;29.1,3.88,;30.43,3.11,;30.43,1.57,;29.09,.81,;29.09,-.73,;30.43,-1.5,;31.76,-.74,;31.76,.81,;33.09,1.58,;34.43,.82,;35.9,1.3,;36.81,.04,;35.9,-1.21,;36.38,-2.68,;35.35,-3.82,;33.84,-3.49,;32.81,-4.63,;33.28,-6.1,;32.24,-7.24,;34.79,-6.42,;35.83,-5.28,;34.43,-.74,;33.09,-1.51,;36.38,2.76,;37.88,3.08,;38.36,4.54,;37.33,5.69,;35.82,5.36,;35.35,3.9,;27.77,1.57,;27.76,3.1,)| Show InChI InChI=1S/C26H30N6O/c1-33-22-13-9-18(10-14-22)15-28-26-29-16-23-24(20-5-3-2-4-6-20)31-32(25(23)30-26)17-19-7-11-21(27)12-8-19/h2-6,9-10,13-14,16,19,21H,7-8,11-12,15,17,27H2,1H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...				US Patent US9744172 (2017) BindingDB Entry DOI: 10.7270/Q2PR7Z30
					More data for this Ligand-Target Pair