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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM125676'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM125676
PNG
(US8772305, 71)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cc(OCC(C)(C)CO)ccn3)ccc2[nH]1
Show InChI InChI=1S/C28H33N7O3/c1-28(2,17-36)18-38-21-6-8-29-24(16-21)23-7-9-30-27(33-23)31-20-4-5-22-19(14-20)15-25(32-22)26(37)35-12-10-34(3)11-13-35/h4-9,14-16,32,36H,10-13,17-18H2,1-3H3,(H,30,31,33)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8772305 (2014)


BindingDB Entry DOI: 10.7270/Q2KH0M0H
More data for this
Ligand-Target Pair