new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM140284'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140284
PNG
(US8912173, 10)
Show SMILES COc1cc(ccc1OC(C)C)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r|
Show InChI InChI=1/C25H28N2O4/c1-15(2)30-22-8-7-17(11-24(22)29-4)18-10-21-20(6-5-9-26-21)23(12-18)31-16(3)19-13-25(28)27-14-19/h5-12,15-16,19H,13-14H2,1-4H3,(H,27,28)/t16-,19-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair