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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM140314'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140314
PNG
(US8912173, 40)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H26N4O3/c28-27(32)23-4-2-10-30-25(23)18-34-26-16-21(15-24-22(26)3-1-9-29-24)20-7-5-19(6-8-20)17-31-11-13-33-14-12-31/h1-10,15-16H,11-14,17-18H2,(H2,28,32)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM140314
PNG
(US8912173, 40)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H26N4O3/c28-27(32)23-4-2-10-30-25(23)18-34-26-16-21(15-24-22(26)3-1-9-29-24)20-7-5-19(6-8-20)17-31-11-13-33-14-12-31/h1-10,15-16H,11-14,17-18H2,(H2,28,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.40n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair