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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM144502'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144502
PNG
(US8969568, 55)
Show SMILES COc1cc(ccc1O[C@@H]1CCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C24H25N3O5/c1-29-22-10-16(4-5-21(22)32-17-6-8-30-14-17)19-11-20-18(3-2-7-25-20)24(27-19)31-13-15-9-23(28)26-12-15/h2-5,7,10-11,15,17H,6,8-9,12-14H2,1H3,(H,26,28)/t15-,17-/s2
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair