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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM144568'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144568
PNG
(US8969568, 121)
Show SMILES C[C@@H](Oc1nc(cc2ncccc12)-c1ccc(cc1)C#N)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C21H18N4O2/c1-13(16-9-20(26)24-12-16)27-21-17-3-2-8-23-19(17)10-18(25-21)15-6-4-14(11-22)5-7-15/h2-8,10,13,16H,9,12H2,1H3,(H,24,26)/t13-,16-/s2
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair