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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM172943'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172943
PNG
(US9096579, 45)
Show SMILES CN1CCN(C2CCN(CC2)C(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(Cl)c3[nH]2)C1=O
Show InChI InChI=1S/C26H28ClN9O2/c1-33-14-22(29-15-33)20-3-6-28-25(32-20)30-17-11-16-12-21(31-23(16)19(27)13-17)24(37)35-7-4-18(5-8-35)36-10-9-34(2)26(36)38/h3,6,11-15,18,31H,4-5,7-10H2,1-2H3,(H,28,30,32)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair