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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM173010'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173010
PNG
(US9096579, 112)
Show SMILES Cc1c(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)cnn1C
Show InChI InChI=1S/C24H25N9O/c1-14-7-18(29-24-25-6-5-19(31-24)21-12-32(3)13-27-21)8-16-9-20(30-22(14)16)23(34)26-10-17-11-28-33(4)15(17)2/h5-9,11-13,30H,10H2,1-4H3,(H,26,34)(H,25,29,31)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173010
PNG
(US9096579, 112)
Show SMILES Cc1c(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)cnn1C
Show InChI InChI=1S/C24H25N9O/c1-14-7-18(29-24-25-6-5-19(31-24)21-12-32(3)13-27-21)8-16-9-20(30-22(14)16)23(34)26-10-17-11-28-33(4)15(17)2/h5-9,11-13,30H,10H2,1-4H3,(H,26,34)(H,25,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair