Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM182052'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182052 (US9145391, 1-20) Show SMILES COC1CC(Cc2ccc(cn2)-c2cc(C)cc(Nc3cc(ccn3)C(F)(F)F)n2)CCC1C(O)=O Show InChI InChI=1S/C26H27F3N4O3/c1-15-9-21(32-24(10-15)33-23-13-18(7-8-30-23)26(27,28)29)17-4-5-19(31-14-17)11-16-3-6-20(25(34)35)22(12-16)36-2/h4-5,7-10,13-14,16,20,22H,3,6,11-12H2,1-2H3,(H,34,35)(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
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