Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM182240'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182240 (US9145391, 12) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(nc1)C(C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:29.35,wD:26.28,(2.67,-6.93,;1.33,-6.16,;,-6.93,;-1.33,-6.16,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-3.79,;-6.67,-4.62,;-6.67,-6.16,;-5.33,-6.93,;-5.33,-2.25,;-6.67,-1.48,;-4,-1.48,;-1.33,-4.62,;,-3.85,;1.33,-4.62,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;1.33,,;1.33,-1.54,;,2.31,;-1.33,1.54,;-1.33,3.08,;1.33,3.08,;2.67,2.31,;4,3.08,;4,4.62,;2.67,5.39,;1.33,4.62,;5.33,5.39,;6.67,4.62,;5.33,6.93,)| Show InChI InChI=1S/C26H28F2N4O3/c1-15-11-20(31-23(12-15)32-22-13-17(24(27)28)9-10-29-22)18-5-8-21(30-14-18)26(2,35)19-6-3-16(4-7-19)25(33)34/h5,8-14,16,19,24,35H,3-4,6-7H2,1-2H3,(H,33,34)(H,29,31,32)/t16-,19-,26?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
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