Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM182298'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM182298 (US9145391, 12-2) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(C[C@H](O)C2CCC(CC2)C(O)=O)nc1 |wD:22.24,(11.91,-5,;10.58,-4.23,;9.25,-5,;7.91,-4.23,;6.58,-5,;6.58,-6.54,;7.91,-7.31,;7.91,-8.85,;6.58,-9.62,;5.25,-8.85,;5.25,-7.31,;9.25,-9.62,;10.58,-8.85,;9.25,-11.16,;7.91,-2.69,;9.25,-1.92,;10.58,-2.69,;9.25,-.38,;7.91,.39,;7.91,1.93,;9.25,2.7,;9.25,4.24,;7.91,5.01,;6.58,4.24,;7.91,6.55,;9.25,7.32,;9.25,8.86,;7.91,9.63,;6.58,8.86,;6.58,7.32,;7.91,11.17,;6.58,11.94,;9.25,11.94,;10.58,1.93,;10.58,.39,)| Show InChI InChI=1S/C26H28F2N4O3/c1-15-10-21(31-24(11-15)32-23-12-18(25(27)28)8-9-29-23)19-6-7-20(30-14-19)13-22(33)16-2-4-17(5-3-16)26(34)35/h6-12,14,16-17,22,25,33H,2-5,13H2,1H3,(H,34,35)(H,29,31,32)/t16?,17?,22-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp.; Merck Canada Inc. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9145391 (2015) BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
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